TP53 and thyroid gland carcinoma: On the basis of KEGG pathway analysis, it demonstrated that the 10 most significant enrichment pathways of downregulated DEGs were thyroid cancer, citrate cycle (TCA cycle), p53 signaling pathway, tyrosine metabolism, melanoma, bacterial invasion of epithelial cells, TGF-beta signaling pathway, ribosome, Huntington's disease, and human papillomavirus infection (Figure 3(d)).