It is well acknowledged that HADC participates in cellular modulation in various cells by regulating miRNAs, for example, HDAC2 regulates miR-503-5p in esophageal squamous cell carcinoma [35], HDAC2 promotes the endothelial dysfunction induced by diabetes [36, 37], and HDACs regulate the cellular differentiation in neurodegenerative diseases [38]. Here, HDAC2 is linked to neurodegenerative disease.