FUS and amyotrophic lateral sclerosis: Moreover, we also observed increased partitioning of TDP-43, hnRNP A1, hnRNP H, hnRNP U and other RBPs from the soluble to the detergent-insoluble fractions of the FUSP525L ALS brain, showing that, in patients with ALS-FUS, as in the mutant mice, FUS drives the insolubility of related RBPs, including TDP-43 (Fig. 2f).