TF and Hepatic fibrosis: From this perspective, it is interesting to note that we recently reported that transferrin plays an important role in both high dietary iron-induced liver fibrosis and carbon tetrachloride (CCl4)-induced liver fibrosis in mice, and inhibiting ferroptosis potently prevented these effects; in addition, we found that clinical data support the role of transferrin in protecting against liver fibrosis by blocking ferroptosis, providing a possible therapeutic target for preventing ferroptosis-induced liver fibrosis [26].