One report showed that GSK3β inhibition results in activation of c-Myc and increase of DNA methylation in O6-methylguanine DNA methyltransferase (MGMT) promoter by c-Myc-dependent recruitment of DNA (cytosine-5)-methyltransferase 3A, and, therefore, GSK3β inhibition enhances TMZ effect in GBM cells52. This evidence concerns the gene GSK3B and glioblastoma.