The final AD model, combining the 10-protein and APOE ɛ4 carrier models, had an AUC value of 0.873 (95% CI 0.813 to 0.933) and a balanced accuracy value of 79.9% (95% CI 73.2 to 86.6) and improved its sensitivity to 89.9% (95% CI 88.6 to 91.3), higher than that of the other models (Fig. 3B). Here, APOE is linked to Alzheimer disease.