Among the 16 proteins that were used in the final 2 models, 6 (APOA4, B2M, CALR, F13A1, FGA, and TF) were related to AD in the brain and CSF in a cohort study by Johnson et al.22; 4 proteins (B2M, FGA, F13A1, and TF) belonged to modules that were related to blood, myelin or oligodendrocyte, and microglia. Here, CALR is linked to Alzheimer disease.