To validate the performance of the final model, termed the Alzheimer disease (AD) model, and demonstrate improvement in the performance of the multimarker panel compared with the single test, we compared the 10-protein model with the APOE ɛ4 carrier model (Fig. 3A), which had AUC values of 0.817 (95% CI 0.749 to 0.855) and 0.662 (95% CI 0.651 to 0.754), respectively. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.