Further, associations between AD and other proteins in our models have been reported in AD studies on inflammation (C9,CALR)36, Aβ plaque formation (APOB, FN1, APOA4, LAMP2)37–39, and neuronal and brain damage, such as glutamate accumulation in the synapses (MTDH)40 and synaptic plasiticity (ADIPOQ)41. This evidence concerns the gene APOA4 and Alzheimer disease.