Further, associations between AD and other proteins in our models have been reported in AD studies on inflammation (C9,CALR)36, Aβ plaque formation (APOB, FN1, APOA4, LAMP2)37–39, and neuronal and brain damage, such as glutamate accumulation in the synapses (MTDH)40 and synaptic plasiticity (ADIPOQ)41. Here, CALR is linked to Alzheimer disease.