The importance of such gene in eye health is proved by the evidence that Wagner syndrome, a rare inherited vitreoretinopathy, is caused by mutations in the canonical consensus sites of VCAN. Despite the mobilization of such regeneration factors, treatment with rhNGF reveals also high in situ inflammation, well known clinically, but not described so far from a molecular point of view, as reported by the downstream pathways highlighted. The gene discussed is VCAN; the disease is vitreoretinal degeneration.