To better define the role of microglia under NASH, a microglial and macrophage-specific calcium-binding protein, named ionized calcium-binding adaptor molecule 1 (IBA1), and the transmembrane protein 119 (TMEM119), expressed on microglia-derived cells but not on recruited blood-derived macrophages44 were marked. The gene discussed is AIF1; the disease is metabolic dysfunction-associated steatohepatitis.