YTHDF1 was positively correlated with TMB in adrenocortical carcinoma, stomach adenocarcinoma, sarcoma, prostate adenocarcinoma, pancreatic adenocarcinoma, ovarian serous cystadenocarcinoma, lung adenocarcinoma (LUAD), brain lower-grade glioma, head and neck squamous cell carcinoma (HNSC), breast invasive carcinoma (BRCA), and bladder urothelial carcinoma (BLCA), while it was negatively correlated with TMB in colon adenocarcinoma (COAD). Here, YTHDF1 is linked to head and neck squamous cell carcinoma.