YTHDF1 was positively correlated with MSI in BLCA, uterine corpus endometrial carcinoma, lung squamous cell carcinoma, LUAD, liver hepatocellular carcinoma, kidney renal clear cell carcinoma, esophageal carcinoma, and COAD, but it was negatively correlated with MSI in kidney chromophobe, HNSC, and lymphoid neoplasm diffuse large B-cell lymphoma. The gene discussed is YTHDF1; the disease is colon adenocarcinoma.