KRAS and familial pancreatic carcinoma: We next performed 2D adherent, 3D non-adherent, and colony formation assays and observed anti-proliferative effects of TH-Z835 for two KRAS(G12D)-bearing pancreatic cancer cell lines: PANC-1 and KPC (KrasLSL.G12D/+; p53R172H/+; PdxCretg/+).