Systemic values of IL-1β (p = 0.001), IL-6 (p = 0.001), IL-10 (p = 0.026), IL-23 (p = 0.001), IL-33 (p = 0.001), and Gal-1 (p = 0.001) were significantly higher in COVID-19 patients in stage III compared to patients in stage I and II (Fig. 1). This evidence concerns the gene IL6 and COVID-19.