Evaluating the impact of VEGFR2-TKIs and propranolol combination therapy in vitro and in vivo reminded us that the stress levels of patients could be associated with sensitivity to VEGFR2-TKIs, and psychological rehabilitation intervention improves the clinical efficacy of anti-VEGFR2 therapy in NSCLC patients. The gene discussed is KDR; the disease is non-small cell lung carcinoma.