ADRB2 and non-small cell lung carcinoma: In this study, we showed a positive relationship between the IC50 value of apatinib and ADRB2 expression in the four different NSCLC cell lines tested, which possibly confirms the association between sensitivity to apatinib and ADRB2 expression in NSCLC; however, the difference was not statistically significant (P = 0.0801), almost certainly due to the small sample size.