Banerjee et al. revealed that stress reduction significantly reduces the growth of NSCLC xenografts in mice compared with mice maintained under controlled conditions [40], which is similar to the finding that enhanced VEGFR2 expression significantly increased tumors in the mouse model of repeated social defeat stress (RSDS) [41], suggesting that chronic stress contributes to tumor progression, invasion, and metastasis and might be associated with VEGF2 secretion. This evidence concerns the gene KDR and neoplasm.