SLC16A3 and neoplasm: We observed a significant increase in the overall MCT4 expression in more aggressive disease (P = 0.02; Fig. 3c, Supplementary Table 5), due to its increased expression on tumour epithelial cells, as demonstrated by a significant increase in the epithelium-to-stroma MCT4 ratio in high %GP4 lesions (Fig. 3d, Supplementary Table 5).