SLC16A1 and neoplasm: This finding is supported by preferential expression of MCT1 in this cellular compartment which facilitates the uptake of the hyperpolarised [1-13C]pyruvate, as well as the increase in combined epithelial LDH and overexpression of MCT4 on tumour epithelial cells in high %GP4 disease, both of which show strong correlations with [1-13C]lactate signal.