LDHA and neoplasm: In high %GP4 tumours, PDHA1 was significantly lower compared to low %GP4 tumours (Supplementary Fig. 3; Supplementary Table 6), while LDHA/PDHA1 was significantly higher (Supplementary Fig. 3; Supplementary Table 6), which provides indirect evidence for a shift from oxidative to glycolytic metabolism associated with the emergence of a more glycolytic cell population.