In addition, GRP78 was shown to be negatively correlated with BAX and positively correlate with another apoptosis marker (Bcl2), EMT markers (E-cad, N-cad) as well as OS markers (SOD2, CAT) in BPH tissues, indicating a significantly positive correlation between GRP78 and OS status, EMT status, as well as apoptosis. The gene discussed is HSPA5; the disease is benign prostatic hyperplasia.