This was paralleled by a significant decrease in NOTCH-1 and TGF-β expression at p.i. day 1, and a slight increase in C/EBP-β (Fig. 5j and Supplementary Figs. S4, S5), a senescence marker often associated with an increased risk of tumor development [47, 50]. The gene discussed is TGFB1; the disease is neoplasm.