Nogo-B expression was significantly related to N stage (P < 0.001), M stage (P = 0.023), clinical stage (P = 0.001), survival state (P = 0.006), recurrence (P = 0.003), locoregional failure(P = 0.592) and distant metastasis failure(P = 0.002) in NPC patients (Table 1). The gene discussed is RTN4; the disease is nasopharyngeal carcinoma.