In our study, we found that in NPC patients, Nogo-B expression was positively correlated with p-RhoA expression, and Nogo-Bhigh p-RhoAhigh was correlated with a poor prognosis of NPC patients, indicating a novel finding that combination of Nogo-B and p-RhoA could develop a more predictive and valuable factor for the prognosis of NPC individuals. Here, RTN4 is linked to nasopharyngeal carcinoma.