It has been shown that Il-3 promotes inflammation and cytokine storms in murine sepsis models.4 To investigate the roles of March3 in sepsis, sex-matched and age-matched March3+/+ and March3−/− mice were subjected to cecal ligation and puncture (CLP) procedures, which have been used as a model for polymicrobial sepsis.20 We found that March3−/− mice treated with CLP and Il-3 produced higher levels of serum Tnf-α, Il-6, and Il-1β than wild-type mice. Here, TNF is linked to Sepsis.