A previous study showed that treatment of cells with an mRNA translation inhibitor, which enhances the aggregation of SG, inhibited SARS-CoV-2 infection in vitro, suggesting that SG is an important innate defense system and may be a novel drug target for treating COVID-19.19,30 This is consistent with the phenomenon that SARS-CoV-2 N protein and NSP5 facilitated VSV infection. Here, SPECC1 is linked to COVID-19.