G3BP1, the nucleating protein of SGs, interacts with RIG-I and promotes its activation.8 In addition, G3BP1 associates with cGAS and enhances the oligomerization and DNA binding activity of cGAS.9 In addition to G3BP1, PKR is critical for both cGAS-STING and RIG-I/MDA5 signaling pathways.10 These phenomena suggest that the two pathways are closely connected and can counteract viral infections. The gene discussed is G3BP1; the disease is viral infectious disease.