By comparing the up- and downregulated genes in Trp53 versus Trp53;Nf2 codeleted tumors against the changes found in Nf2 versus Trp53;Nf2 codeleted tumors, we identified enrichment in signatures for Wnt signaling and Cadherin signaling using PANTHER (Supplementary Fig. S8B) in our model of sarcomatoid ICC. This evidence concerns the gene NF2 and intrahepatic cholangiocarcinoma.