As KPPTom mice show both Wnt and PI3K/AKT activity, we treated them with LGK974 (to inhibit Wnt signaling) and pictilisib (to inhibit Pi3K signaling) at 4 weeks following tumor induction (i.e., the start of Thioacetamide treatment), and a time point at which we know that there is ICC forming in the liver (Fig. 4F), to determine whether a model of well-differentiated ICC is susceptible to coinhibition of these pathways. The gene discussed is AKT1; the disease is neoplasm.