TP53 and intrahepatic cholangiocarcinoma: By comparing the up- and downregulated genes in Trp53 versus Trp53;Nf2 codeleted tumors against the changes found in Nf2 versus Trp53;Nf2 codeleted tumors, we identified enrichment in signatures for Wnt signaling and Cadherin signaling using PANTHER (Supplementary Fig. S8B) in our model of sarcomatoid ICC.