We also found recurrent CRISPR-induced indels from both NRASG12V and KRASG12D screens in genes whose loss has been linked to ICC but that have not previously been shown to genetically interact with mutant RAS in this cancer including Brca2, Nf2, and Plk2 (Fig. 2D). Here, NF2 is linked to intrahepatic cholangiocarcinoma.