TP53 and neoplasm: Tumors that lacked both Trp53 and Nf2 were highly diffuse and covered less liver area compared with both single gene deletions; however, the number of tumors that formed was significantly higher in Trp53;Nf2 codeleted tumors, suggesting that mutations in these two tumor suppressors may synergize in cancer and are not functionally redundant (Fig. 3B and C).