NF2 and cancer: Histopathologically, the Trp53;Nf2 codeleted cancers are highly invasive with CK19 and GFP (KRasG12D-expressing) immunopositive cells migrating throughout the liver (Fig. 3D; Supplementary Fig. S7) and represent a model to study the biology of invasive, sarcomatoid ICCs, which migrate along the ducts and invade the liver (33).