NF2 and intrahepatic cholangiocarcinoma: In fact, of the 14 cancers from our screen that we exome sequenced, four of the five containing Nf2 mutations segregated away from the main cluster (Fig. 2E), suggesting that the addition of a mutation in Nf2 can functionally cooperate with KrasG12D and Trp53 mutations and affects the phenotype of ICC.