Cardiovascular diseases (CVDs) have been linked with TNF by genetic and epidemiological evidence.9, 10, 11, 12, 13, 14, 15, 16 Multiple hypotheses of the biological mechanisms through which TNF may contribute to CVDs were also proposed by the accumulating experimental studies on animal models.17, 18, 19 Recently, using Mendelian randomization (MR) design, Yuan et al. This evidence concerns the gene TNF and cardiovascular disorder.