,52 Given the fact that TNFR2 has higher affinity to transmembrane TNF, supressing TACE, the enzyme that truncates membrane-bound TNF into soluble cytokine, may act similarly as the TNFR2 agonists.1, 2, 3,53 However, due to the lack of valid downstream effectors, we were unable to predict the effect of boosting TNF/TNFR2 signalling via either directly upregulating the receptor or indirectly modulating TACE on CAD or IS. The gene discussed is TNFRSF1B; the disease is coronary artery disorder.