PALB2 and Lynch syndrome: Some germline genetic testing guidelines including the UK National Institute for Health and Care Excellence recommend a pre-test probability of 10% to prompt genetic testing.15 Therefore, we applied two widely used prediction models, the PREMM5 model for Lynch syndrome risk16 and the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) V5 model17 for HRD/DDR gene germline carrier risk (ATM, CHEK2, BRCA1, BRCA2, BRIP1, PALB2, RAD51C and RAD51D) to 126 patients with germline pathogenic variants in these genes.