Indeed, miR-320c downregulates the TGF-β signaling via targeting thrombospondin 1 (TSP-1) [167] that is a key activator of TGF-β in renal fibrosis [168, 169] and shows an elevated expression in the glomeruli of DN patients [170, 171]. This evidence concerns the gene TGFB1 and liver dysplastic nodule.