EDN1 and liver dysplastic nodule: ET1 has been reported to promote insulin resistance [111], to elevate the glomerular permeability and in turn elevate the serum level of creatinine [112], to correlate with the proteinuria level in DN patients [113], to induce proliferation of mesangial cells and accumulation of mesangial matrix [114], and to play a pro-fibrotic role in diabetic complications [115].