Strikingly, studies assessing pro- and/or anti-inflammatory cytokines (IP-10, MCP-1, MIG, RANTES, CC-16 IL-2, IL-4, IL-6, IL-8, IL-10, IL-17a, TNF, IFNγ, sTNFR1, sTNFR2, IL-1β, IL-18, IL-33, IL-37, IL-1Ra, sIL-1R2, IL-18BP, sIL-1R4) in the blood of ALS patients (Table 2) were unable to detect a correlation with ALSFRS-R scores of patients that they assessed at the time of biosample donation [27, 33, 34, 37, 40, 70]. Here, IL1B is linked to amyotrophic lateral sclerosis.