CXCL8 and amyotrophic lateral sclerosis: For instance, transcriptomic analyses of monocytes identified an unique inflammation-related gene expression profile, including altered IL-1B, IL-8, FOSB, C-X-C Motif Chemokine Ligand 1 (CXCL1), and CXCL2 gene expression, which distinguished ALS from control samples [56].