For example, rather than having a negative effect, through inhibiting NF-κB and therefore lentiviral transcription, available studies support the opposite phenomenon: Vpx degradation of HUSH enhances spreading infection of SIVmac in CEMx174 cells and HIV-1 proviral transcription in Jurkat cells with Vpx delivered by VLP [24, 25]. Here, NFKB1 is linked to infection.