For example, during spreading infection in Jurkat T cells, which lack active SAMHD1 and cGAS, WT SIVmac and ∆vpx viruses replicate similarly, unless STING is activated with agonist (RR-S2 CDA), and then Vpx enhances infection, consistent with our data [30, 37]. The gene discussed is STING1; the disease is infection.