Second, compared with controls, MM patients under the age of 60 years had significantly higher levels of leptin (SMD = 1.84, 95%CI: 0.87 to 2.82, Fig. 3B), while those over 60 did not (SMD = 0.27, 95%CI: -0.06 to 0.59, Fig. 3B). This evidence concerns the gene LEP and Miyoshi myopathy.