Furthermore, in the subgroup of case size less than 50, MM patients had significantly higher leptin levels than controls (SMD = 1.39, 95%CI: 0.27 to 2.50, Fig. 3C), which was not true in the subgroup of case size more than 50 (SMD = 0.34, 95%CI: -0.06 to 0.74, Fig. 3C). This evidence concerns the gene LEP and Miyoshi myopathy.