First, higher levels of circulating leptin were observed in overweight (SMD = 0.49, 95%CI: 0.06 to 0.93, Fig. 3A) and normal weight (SMD = 2.27, 95%CI: 0.68 to 3.86, Fig. 3A) MM patients than in controls. The gene discussed is LEP; the disease is Miyoshi myopathy.