Overall, these data indicate that NAIP and NLRC4 are partially required for inflammasome responses to Salmonella infection in human macrophages, in contrast to what we observe with individual T3SS ligand delivery (Figs 1, S3 and S4), where NAIP/NLRC4 is absolutely required for inflammasome activation. Here, NLRC4 is linked to Salmonella Infections.