DEGS1 and diabetes mellitus: This is the case of relevant proteins in the biomedical context such as AGMO, an enzyme that has been linked to numerous diseases such as cancer and diabetes [30], DEGS1, another enzyme with a critical role in lipid metabolism [31], or PEMT, another lipid metabolism enzyme and was amongst the first genes associated with non-alcoholic fatty liver disease [32] (Fig 2E–2G respectively).