This is in line with studies in humans, showing a reduction or functional impairment of IL-10-producing Bregs in active autoimmune diseases like systemic sclerosis [78,79], ANCA-associated vasculitis [80,81], RA [82–84], or systemic lupus erythematosus [73]. This evidence concerns the gene IL10 and anti-neutrophil cytoplasmic antibody-associated vasculitis.