SH2B1 and Down syndrome: Limited clinical evidence suggested that a distal gene in 16p11.2 locus, SH2B adaptor protein 1 (SH2B1), was the candidate affecting the weight status in patients with 16p11.2 syndrome, due to its function in regulating leptin sensitivity.[43] Arbogast et al[13] reported an obese phenotype along with a declined endocrine level of leptin in the Sultal‐Spn DP model with high‐fat diet.