“HER2”; “apoptosis”; “breast cancer”; “lapatinib”; “autophagy”; “combination therapy”; “neratinib”; “c-Met”; “gastric cancer”; “glioblastoma”; “AKT”; proliferation”; “nanoparticles”; “ERK”; “pancreatic cancer”; “reactive oxygen species”; “cancer stem cell”; “chemoresistance”; “Src”; “hepatotoxicity”; “oxidative stress”; “cell cycle”; “pyrotinib”; “radiation”; “PI3K”; “mitochondria”; “trastuzumab”; “migration”; “NF-kappa B”; “gemcitabine”; “drug delivery”; “glioma”; “triple-negative breast cancer”; “diarrhea”; “adjuvant therapy”; “metastatic breast cancer”; “PI3K/AKT”; “invasion”. The gene discussed is AKT1; the disease is breast carcinoma.