These highly concentrated evolutionary venations indicate scholars’ continuous and steady focus on NSCLC, CML, renal cell carcinoma, chronic lymphocytic leukemia, etc. These different evolutionary lines show a clear development path: TKIs research is disease focused and revolved around “gene targets/targeted drugs/resistance mechanisms.” For example, in the CML venation, investigators focused on the BRC-ABL in 2016 and on dasatinib and nilotinib in 2017-2020, which could both target BCR-ABL and overcome imatinib resistance [72,73]. The gene discussed is ABL1; the disease is hereditary clear cell renal cell carcinoma.