In the renal cell carcinoma venation, investigators continued to focus on various TKIs such as sunitinib, sorafenib, regorafenib, and pazopanib, and also paid attention to gene targets such as PDGFR, FGFR, c-Kit, and VEGF, and multidrug resistance. The gene discussed is PDGFRB; the disease is hereditary clear cell renal cell carcinoma.