The first echelon includes C1 (NSCLC), which contains EGFR, EGFR-TKI, EGFR mutation, lung cancer, erlotinib, etc.; and C2 (targeted therapy), which contains renal cell carcinoma, sunitinib, chemotherapy, cancer, tumor, etc. These 2 major subdirections contain the largest number of keywords and the largest sum of frequencies, which are the main subdirections of TKIs research. This evidence concerns the gene EGFR and hereditary clear cell renal cell carcinoma.