Given the fact that obesity is a comorbidity in all of these human diseases, here we set out to determine whether selective small molecule inhibition of the gut microbial choline transformation into TMA, a metabolic activity catalyzed by the microbial choline TMA lyase CutC (Craciun and Balskus, 2012), can protect against metabolic disturbance in preclinical mouse models of obesity. This evidence concerns the gene CUTC and Obesity.