DR has a plethora of pathways associated with hyperglycemia-induced retinal damage that including increased oxidative stress [5], advanced glycation end products (AGEs) accumulation [6], change in the level of transforming growth factor beta (TGFβ) [5], increased inflammation responses [7], and vascular endothelial growth factor (VEGF) [8]. Here, VEGFA is linked to Hyperglycemia.