Furthermore, local application of the non-specific NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), to the carotid sinus abolishes the inhibition of baroreceptor activity and the increases in carotid artery diameter in eNOS-transduced carotid sinuses suggesting that adenoviral-mediated gene transfer of eNOS to carotid sinus adventitia causes a NO-dependent inhibition of the baroreceptor mechanism, including a reset of the baroreceptor reflex in response to high blood pressure [176]. Here, NOS3 is linked to blood pressure trait.