Agonists and antagonists of the sGC enzyme can be a future novel class of “repair” medications that can modify the oxidatively damaged sGC enzyme, and thereby can be prescribed for the treatment of not only pulmonary hypertension or heart failure, but also in other situations such as hypertension, erectile dysfunction, atherosclerosis, restenosis, thrombosis, and inflammation [83]. Here, SGCB is linked to heart failure.