Following stimulation with a forskolin (fsk) and IBMX cocktail, rectal biopsies from the I37R/F508del CF participant elicited cAMP-dependent currents of 45.8 ± 3.8 μA/cm2—an appreciable 50% of WT-CFTR activity (p < 0.05; Figure 1A, Table S3). The gene discussed is CFTR; the disease is cystic fibrosis.