The proposed paracrine-signaling pathway of paraneoplastic thrombocytosis [3,4] includes the overproduction of various cytokines (e.g., interleukin-6) by the tumor, which causes increased hepatic thrombopoietin production that modulates the production of platelets within the bone marrow, ultimately resulting in an increased platelet count. This evidence concerns the gene THPO and Thrombocytosis.