The proposed paracrine-signaling pathway of paraneoplastic thrombocytosis [3,4] includes the overproduction of various cytokines (e.g., interleukin-6) by the tumor, which causes increased hepatic thrombopoietin production that modulates the production of platelets within the bone marrow, ultimately resulting in an increased platelet count. The gene discussed is THPO; the disease is thrombocytosis disease.