We found that several hub genes, such as AURKA, TP53, CDK1, CDK2, CCNB1, PLK1, CUL1, ESR1, CDC20, and PIK3CA, and correlative pathways, including regulation of actin cytoskeleton, FcγR-mediated phagocytosis, proteoglycans in cancer, focal adhesion, and ErbB signaling pathway, may be of diagnostic or therapeutic potential for ENKL. This evidence concerns the gene CUL1 and cancer.