FOXD2 and central nervous system cancer: FOXD2-AS1 expression was correlated with invasion, migration, and low apoptosis of cancer cells and a poor outcome of patients with these tumors.237, 238, 239, 240 FOXD2-AS1 could lead to glioma progression by modulating the PI3K/AKT signaling pathway and also the miR-185-5p/high-mobility group 2 (HMGA2) axis.241