It has been shown that the mesenchymal stem cells (MSCs) present in GSC niches promote a proliferative and regenerative environment, which can stimulate GSCs in vitro, possibly through the interleukin-6 (IL-6)/STAT3 signaling pathway, with the resultant induction of glioma-associated human MSCs (GA-hMSCs) in vivo.33 Here, IL6 is linked to central nervous system cancer.