MiR-29a can not only directly inhibit the expression of LIFR-AS1 in colorectal cancer cells but can also inhibit LIFR-AS1 and the formation of colorectal cancer by promoting the expression of TNFAIP3; meanwhile, LIFR-AS1 can serve as a sponge for miR-29a, which, in turn, inhibits the TNFAIP3 expression. This evidence concerns the gene LIFR and colorectal cancer.