STUB1 and atherosclerosis: Although the pathology primarily hampered by CHIP is atherosclerosis, recent evidences suggested that valve disease may be also affected by this new risk condition, as shown in two recent studies reporting the association of DNMT3A and TET2 CHIP-mutations with increased inflammatory cytokines secretion by innate immunity cells, and an increased risk of severe aortic valve stenosis, also connected to poor survival after implantation of transcatheter valve implants (TAVI) (108, 109).