An ancestral study on Sri Lankan population comprising of 95 men, screened for ApoA-I/C-III/A-IV-SstI associated SNPs showed higher risks for CHD (42), and the reports of African-American type 2 diabetic population consisting of 168 subjects had confirmed APOC III levels alone serve as the major risk factors of metabolic syndromes with decreased TG and HDL levels contributing to the high risks of CHD and dyslipidemia in the Tri-ethnic groups chosen (white Non–Hispanics, African-American, and Hispanics) (43). The gene discussed is APOC3; the disease is metabolic syndrome.