Interestingly, taking the network of target genes impacted by these miRNAs as a whole, it is suggestive to note that, besides LDLR, the majority of targets are related to inflammatory pathways (e.g., TLR4, STAT3, CRP, IL6, IFN-γ, TNF-α, etc.)pointing out that the role of PCSK9 on atherosclerosis has to be thought also in the context of an inflammatory autocrine/paracrine loop (46–49). The gene discussed is IL6; the disease is atherosclerosis.