A genetic score combining three genetic variants (PNPLA3 p.I148M, TM6SF2 p. E167K and HSD17B13 rs72613567) for fatty liver disease conferred up to a 12-fold higher risk of cirrhosis and up to a 29-fold higher risk of HCC in individuals from the general population (Gellert-Kristensen et al., 2020). The gene discussed is HSD17B13; the disease is fatty liver disease.