HSD17B13 and metabolic dysfunction-associated steatotic liver disease: Surprisingly, a recent study on HSD17B13 gene knockout mice showed that HSD17B13 deficiency failed to protect the liver from high-fat diet-, Western diet- and alcohol exposure-induced steatotic damages, indicating that HSD17B13 deficiency might not have a protective role in murine NAFLD models (Ma et al., 2021).