Interestingly, a few human HSD17B13 genetic variants located in various non-coding areas, including rs10433879, rs6834314, rs3923441, rs9992651, and rs72613567 were also reported to be associated with reduced severity of NAFLD (Ma et al., 2019; Namjou et al., 2019; Whitfield et al., 2019; Anstee et al., 2020; Satapathy et al., 2021) (Table 1). This evidence concerns the gene HSD17B13 and metabolic dysfunction-associated steatotic liver disease.