TM6SF2 and fatty liver disease: In addition, Stender’s group has recently reported that an unweighted genetic risk score combining three genetic variants including PNPLA3p.I148M, TM6SF2 p.E167K and HSD17B13 rs72613567 for fatty liver disease conferred up to a 12-fold higher risk of cirrhosis and up to a 29-fold higher risk of HCC in individuals from the general population in Europe (Gellert-Kristensen et al., 2020).