Song et al. (2020) identified circRNA_0000253 as one of the most upregulated circRNAs in the exosomes released from the degenerative NP cells. Functionally, circRNA_0000253 could promote IDD development via downregulating SIRT1 and sponging miRNA-141-5p in vitro and in vivo. Here, SIRT1 is linked to intervertebral disk degenerative disorder.