Guo et al. (2018) showed that circ-GRB10 was decreased in NP samples from IDD patients as compared to normal NP samples. Enforced expression of circ-GRB10 suppressed NP cell apoptosis. Mechanistically, circ-GRB10 targeted miR-328-5p to derepress ERBB2 to positively regulate cell proliferation. Circ-GRB10 suppressed IDD development in the rat model. Moreover, the upstream mechanism underlying circ-GRB10 dysregulation was elucidated. Guo et al. (2020b) found that FUS could promote circ-GBR10 biosynthesis in the NP cells in which FUS expression was regulated by miR-141-3p. Here, ERBB2 is linked to intervertebral disk degenerative disorder.