Emerging studies have pointed to the involvement of non-coding RNAs, including miRNAs, long non-coding RNAs and circRNAs (Figures 1, 2, 3 and 4; Table 1), in IDD through their extensive crosstalk with NP cell function-related signaling pathways, such as Wnt and NF-κB signaling. The gene discussed is NFKB1; the disease is intervertebral disk degenerative disorder.