TRPM2 and neoplasm: Although, in a small number of malignancies, the activation rather than the inhibition of TRPM2 has been reported to reduce tumor cell survival (Di et al., 2012), most of the studies considered that inhibition of the expression or function of TRPM2 resulted in decreased tumor proliferation and/or viability in several malignancies (Klumpp et al., 2016; Belrose and Jackson, 2018).