Moreover, the level of TRPM2 was significantly lower in glioblastoma multiforme (GBM) and brain lower-grade glioma (LGG) than that in normal tissue, while no significant differences were detected in sarcoma (SARC), testicular germ cell tumors (TGCT), adrenocortical carcinoma (ACC), diffuse large B-cell lymphoma (DLBC), kidney chromophobe (KICH), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), pheochromocytoma and paraganglioma (PCPG), thyroid carcinoma (THCA), and thymoma (THYM) (Figures 1B, C). This evidence concerns the gene TRPM2 and paraganglioma.