Knockdown/inhibition of TRPM2 impaired mitochondrial function and autophagy, reduced cellular bioenergetics, and increased the levels of reactive oxygen species (ROS), resulting in decreased tumor proliferation and/or viability in many malignancies, suggesting a role of TRPM2 in cancer cell propagation and growth (Hopkins et al., 2015; Miller, 2019). Here, TRPM2 is linked to neoplasm.