TRPM2 and adrenal cortex carcinoma: Moreover, the level of TRPM2 was significantly lower in glioblastoma multiforme (GBM) and brain lower-grade glioma (LGG) than that in normal tissue, while no significant differences were detected in sarcoma (SARC), testicular germ cell tumors (TGCT), adrenocortical carcinoma (ACC), diffuse large B-cell lymphoma (DLBC), kidney chromophobe (KICH), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), pheochromocytoma and paraganglioma (PCPG), thyroid carcinoma (THCA), and thymoma (THYM) (Figures 1B, C).