It was found that denture wearing during sleep would increase the risk of incident pneumonia in the elderly and the elderly having this behavior were more likely to have tongue and denture plaque, gum inflammation, positive culture for C. albicans, and higher levels of circulating IL-6 as compared with those who remove their dentures at night, suggesting potential implications of oral hygiene programs for pneumonia prevention in the community (Iinuma et al., 2015). This evidence concerns the gene IL6 and pneumonia.