HIF1A and Insulin resistance: The volcano plots showed differences in PBMC gene expression between AR and non-AR (Figure 1A), and only the top 20 significantly expressed genes are shown in Figure, including several important genes, such as C1QC, VEGFA, IRAK2, HIF1A, and SERPINE1, which are closely associated with the immune system, growth of peripheral blood vessels, suppression of oxidative phosphorylation and fatty acid oxidation, and systemic insulin resistance (19–22).