CREBBP and neoplasm: In FL, CREBBP mutations are founder events, occur early and contribute to immune escape by downregulating MHC-II expression (Green et al., 2015; García-Ramírez et al., 2017), which is crucial for GC B-cell differentiation (Allen et al., 2007) and tumor-Ag presentation (Khodadoust et al., 2017).