As an example relevant for GCB lymphomagenesis, conditional deletion of the histone acetyltransferase CREBBP perturbs B-cell development and accelerates the development of lymphoma in BCL2-and MYC-driven mouse models (García-Ramírez et al., 2017; Hashwah et al., 2017; Jiang et al., 2017; Zhang et al., 2017). This evidence concerns the gene BCL2 and lymphoma.