The predictive value of the macrophage marker CD68 alone in lymphoma is debatable, with some studies indicating no predictive value in DLBCL (Matsuki et al., 2019), and others observing correlation with poor prognosis (Cai et al., 2012; Nam et al., 2014; Riihijarvi et al., 2015). Here, CD68 is linked to diffuse large B-cell lymphoma.