EP300 and diffuse large B-cell lymphoma: In addition, EP300, which is also responsible for H3K27Ac and whose LOF mutations are found in GCB-DLBCL and FL (Cerchietti et al., 2010), partially compensates for the function of CREBBP, and EP300 may be critical for CREBBP-deficient B-cell survival (Meyer et al., 2019).