The survival disadvantage of EZB/C3 DLBCLs may be at least partially explained by the fact that the mutational characteristics of double hit (DHIT) lymphomas, an aggressive subtype of DLBCL characterized by MYC and BCL2 translocation, are enriched in this category (Ennishi et al., 2019a; Sha et al., 2019; Wright et al., 2020). The gene discussed is BCL2; the disease is lymphoma.