B-cell lymphomas are unique given the fact that these tumor cells arise from professional antigen presenting cells (APCs)—a specialized subset of immune cells able to capture and optimally present antigens (Ags) to T cells through both MHC (major histocompatibility complex)-I and MHC-II routes (de Charette et al., 2016). This evidence concerns the gene HLA-C and B-cell non-Hodgkin lymphoma.