TYK2 and neoplasm: This interaction can trigger the STAT3 (signal transducer and activator of transcription 3) pathway via phosphorylation of Tyk2 (tyrosin kinase 2) in B cells, with consequent induction of the immunoregulatory cytokines IL-10 and IL-6 (Herrmann et al., 2017), which facilitates immune evasion and supports tumor growth.