Enrichment analysis using KEGG (Figure 3D) and GO (Figure 3E) of the 9 TFs, including JUNB, CEBPD, IRF1, CEBPB, SPL1, IKZF1, CEBPA, BACH1, RUNX3, suggested that the TNF signaling pathway, transcriptional mis-regulation in cancer, regulation of transcription involved in G1/S transition of mitotic cell cycle may serve vital roles. This evidence concerns the gene RUNX3 and cancer.