While NPC1 (Niemann-Pick disease, type C1) on lysosomes and ABCD1 (ATP Binding Cassette Subfamily D Member 1) on peroxisomes are indispensable for the formation of lysosome-peroxisome membrane contact (LPMC), Syt7 allows for the stabilization of these sites by binding to PI-4,5-P2 on the peroxisome. This evidence concerns the gene ABCD1 and Niemann-Pick disease type C.