Our previous work demonstrated that PI5P4Ks are essential for tumor formation upon loss of p53, suggesting the PI5P4Ks are attractive targets for p53 mutant cancers (Emerling et al., 2013) and become relevant in regulating autophagosome-lysosome fusion under these conditions (Lundquist et al., 2018). The gene discussed is TP53; the disease is neoplasm.