In addition, CD14 (Supplementary Figure S2B) and MAP4K4 (Supplementary Figure S2C) were highly enriched in hydroxymethylation for patients with COVID-19 (p = 0.00033 and 0.044), and the levels of hydroxymethylation increased gradually in groups moderate, severe, and critical patients and MI. The gene discussed is MAP4K4; the disease is COVID-19.